![]() Um, And the reason is cuz humans weren’t in, in Spain at that time 64,000 years ago.Īnd there’s a picture that I have in the show notes. Alex: and those cave paintings are actually speculated to be drawn by Neanderthals, not, not humans. Alex: and th those were found in Spain, um, not that long ago, like 10 years ago. Alex: the earliest cave paintings we have are 64,000 years old. Brian: you gonna go to like cave drawings. We can actually go further back than that. So you guessed Egypt, right? Hieroglyphics. Um, soUm, so, ho hopefully, ou enjoy that and it’ll be a good reason to listen. I, I do think, um, if you’re into tidbits, there’s some good tidbits in here. ![]() Brian: So this is, this is gonna be little dense and foundational, but to set up an understanding for all that will follow But, um, I think there’s interesting context here, especially when we get, into the mid 1940s, there’s a lot of stuff that occurs that happens because of what happens before superheroes. So, so functionally, no if, if you wanted to skip this episode and go straight to the creation of Batman, you could go to episode two. Alex: at the very, very end, we’ll talk a very, very little bit about Batman. Brian: So it just outta curiosity, you kind of hinted at this a little before we started the is, are we going to get to Batman this one? this all just like foundational setup? So, yeah, because of this dispute where people like have different definitions of what a comic is, um, we’re, we’re gonna go way back. Um, but you know, and I, I don’t wanna get into it too deep, but like he basically says that, you know, potentially there’s an element where, um, you know, juxtaposed words and art is part of that.ĭo you even really have to be sequential to be a comic? So like family circus right is like a famous single panel comic. Alex: what’s, what’s fun about understanding comics is it itself is actually a comic book. Alex: I will link all of the books in, in the show notes. Brian: Is, we gonna have like a, a link to that book in the description or I, I, I will talk about, today and there’s several, this is the one that like is worth reading. There’s a book, called “Understanding Comics, The Invisible Art” is written by Scott McCloud. In more recent years, people have started to kind of reject that as well. And he wrote a book in the eighties, sort of trying to define what comics were and his, his definition was that it was sequential art. He created a character called the shadow that was famous. So comics and comic strips before superheroes, Will Eisner worked in that time. Um, there’s a couple different people who have had ,uh, different thesis about like what is a comic, that there’s a, a famous artist named Will Eisner, who, worked in what we’re gonna talk about today. Um, and the reason for that is cuz yeah, like you, you, you, you didn’t come fully formed, but there’s actually a lot of debate about what a comic is. Um, and, and we’re, we’re gonna go way, way, way back. Brian: I I’d guess that, like, if we’re talking about comics as like the, the storytelling mechanism for comic books that we’re like familiar with in like a contemporary sense, I probably would guess like 1910s, 1920s, Like as you would expect today, if you say comic or comic book or comic strip, like very readily, like people have something that pops into their head, but that was actualy a slow evolution, like, And that’s cuz you know, they don’t show up fully formed. Alex: Um, we, so we don’t exactly know when the first comics are. Brian: Oh, I mean, I I’d probably say like, Egyptian hieroglyphics Brian: Like Batman comic, or just comic in general? If you had to guess what the first comic was when the first comic happens, what, what would you, what would you guess? And it’s a lot, more than you would think. I’ve done lots of, of prep work to learn about, everything that leads up to the introduction of Batman, to the creation of Batman. And today we’re going to be starting at the very beginning. I am Brian Anders and I am joined today by Alex, the dark night cash. Welcome to bat lessons, the Batman history podcast. Alex: And this is where the word stereotype comes from
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![]() ![]() ![]() ![]() Keith Moon → Legendary, exuberant and innovative drummer for hard rock The Who, “I Can See For Miles” (#9, 1967), recorded one solo album which was issued posthumously, voted #2 in a 2001 readers’ poll by Rolling Stone magazine for the Best Drummers of All Time, died after ingesting an overdose of alcohol withdrawal pills on, age 32.ġ947.Jim Sohns → Founding member and vocals for Chicago blues-pop-rock Shadows of Knight, “Gloria” (#10, 1965), continues to front incarnations of the band on the oldies circuit.ġ946.Pete Fornatale → Award-winning early progressive FM radio DJ, first at WFUV-FM (Fordham University, New York) and, beginning in 1969, on trendsetting WNEW-FM, returned to WFUV in 2001, hosted Sirius XM satellite program, authored several books on rock culture, died from a stroke on, age 66.ġ946.Mick Burt / (Michael Arthur Burt) → Drummer backing Brit novelty pop-“rockney” duo Chas & Dave, “Gertcha” (UK #20, 1979).ġ945.Spaghetti Micale / (Anthony Micale) → Lead vocal for blue-eyed soul/doo wop The Reflections (“(Just Like) Romeo And Juliet,” #6, 1964), continues to perform with the group into the 10s.ġ943.Roger Greenaway → British pop music songwriter and performer, as David was one half the pop vocal duo David & Jonathan, “Michelle” (#18, Adult Contemporary #3, 1966), collaborated with Roger Cook (aka Jonathan) to pen dozens of pop-rock hit singles, including “Long Cool Woman In A Black Dress” ( The Hollies, #2, 1972) and “I’d Like To Teach The World To Sing” ( The New Seekers, #7, 1971).ġ942.Pete Shannon / (Peter Shannon Harris) → Bassist for British Invasion pop-rock The Nashville Teens, “Tobacco Road” (#16, 1964).ġ942.Rudy Lewis / (Charles Rudolph Harrell) → Lead vocals from 1960-1964 for R&B/soul-doo wop The Drifters, “Up On The Roof” (#5, 1963), died in his sleep on, the night before the group recorded “Under The Boardwalk” (#4, 1964) without him, age 27.ġ941.Tex Williams / (Sollie Paul Williams) → “Talking blues” style Western swing singer, songwriter, guitarist and bandleader with ten Country Top 10 hits over a 35 year career, including “Smoke! Smoke! Smoke! (That Cigarette)” (Country #1, 1947), died from pancreatic cancer on, age 68.ġ936.Bob Crosby → Swing-era vocalist and Dixieland bandleader, younger brother of crooner Bing Crosby, fronted authentic New Orleans swing band The Bob-Cats in the 30s, turned to radio in the 40s and became a popular variety program host, scored a hit duet single with Patty Andrews and “The Pussycat Song (Nyot! Nyow! Nyot!)” (#12, 1953), reunited The Bob-Cats for occasional performances until his death from cancer on, age 79.ġ917.Gene Kelly → Broadway and film actor, dancer and adult pop singer, a dominant force in Hollywood musical films of the 40s and 50s, best known for his lead role in the highly-regarded Singin’ In The Rain (1952), died in his sleep on, age 83.ġ913.Malvina Reynolds → Folk-pop singer, songwriter and political activist, wrote “Little Boxes” for Pete Seeger (#70, 1964), “What Have They Done To The Rain?” for The Searchers (#29, 1965), songs covered by Joan Baez, Judy Collins and others, and children’s songs and material for the TV show Sesame Street, died on, age 77.ġ912. ![]() Table 2 Ongoing studies in malignant mesotheliomaįor more than fifteen years, the standard first line treatment has been cisplatin- pemetrexed and it is currently the only regime approved by the Food and Drug Administration (FDA) for MPM. The use of chemotherapy as part of multimodality treatment and targeted therapy for MPM is covered in companion papers in this issue. ![]() ![]() In this review, the current available literature (see Table 1) and ongoing studies (see Table 2) with chemotherapy in the palliative setting and combination strategies in MPM are discussed. Therefore, chemotherapy remains a prominent treatment option in MPM. The first studies with immunotherapy in second and third- line mesothelioma patients seem promising, but their value in the first line setting has yet not been defined ( 6- 9). Immunotherapy, targeting immune checkpoints (like PD-1 or its ligand PD-L1) has become standard of care in numerous solid tumors like non-small cell lung cancer (NSCLC) ( 5). Also, MPM is a heterogeneous tumor type (with three different subtypes) which makes it more challenging to develop effective therapies. This is related to the fact that MPM is mostly driven by loss of tumor suppression genes like CDKN2A, NF2 and BAP1, rather than activation of oncogenes ( 4). In MPM this approach has failed to improve clinical benefit in phase II studies. Use of targeted therapy based on genetic profiling has been successful in other solid tumor types, targeting activating oncogenes. Only a minority of patients is fit enough to be a surgical candidate and the indication for surgery has become stricter in the last years. The European Society for Medical Oncology (ESMO) guidelines, the National Comprehensive Cancer Network (NCCN) guidelines and the European Respiratory Society (ERS) guidelines indicate chemotherapy as an option for patients with ‘irresectable MPM’ who are not fit for major surgery ( 1- 3). Accepted for publication Apr 10, 2018.Ĭhemotherapy is the mainstay of treatment of malignant pleural mesothelioma (MPM). Keywords: Chemotherapy clinical trials malignant mesothelioma ![]() This review focusses on the current standard of chemotherapy and new systemic therapy strategies under investigation. The major challenges are finding optimal treatment combinations and to select the adequate treatment for an individual patient. The clinical benefit of (switch) maintenance therapy after first line treatment and combination strategies of different chemotherapies with angiogenesis inhibitors are currently under investigation. Eventually, all patients will get a recurrence and no active second line therapy has been identified to date. Other anti-angiogenesis agents like thalidomide did not prolong (progression free) survival or response rate. Of the anti-angiogenesis agents, only bevacizumab and nintedanib have shown activity with platinum-pemetrexed doublet therapy. The only registered therapy for MPM is platinum-pemetrexed doublet therapy, although only up to half of patients have clinical benefit from this palliative treatment. Since most patients present with irresectable disease, the vast majority is treated with chemotherapy. Abstract: Malignant pleural mesothelioma (MPM) is an aggressive malignancy with a 5-year survival rate of ~10%. This was not exactly what the customer asked for. The customer felt dejected, and he simply went elsewhere. Offering a discount on a new watch instead of replacing a battery sounds like a company was not listening to the customer’s request and was trying to turn a simple battery replacement into a sale. Refusing to replace a battery seems more like a policy based on the watch being vintage and not a parts shortage. I find it hard to believe that a Watch Service Center would not have any number of batteries in stock or could not easily acquire one. For instance, I found the Hunter Mach 3’s CR2320 3-volt battery for $2.67 on Amazon. They are not rare and almost any imaginable battery is available nowadays. Batteries are consumables that need to be replaced after several years of service. It can be counterargued that a watch battery should never be considered an “unavailable part”. Also, you can see that battery changes are one of the options that the customer may request. To be clear, there is no indication on Swiss Army’s Service Request page that they will not service vintage watches. Taken out of context, this seems like a reasonable thing for a watch company to say, however, we know the context of this repair was a simple battery replacement and not some fancy part. So far everything in the email seems fairly legit, but it’s the next paragraph that states “Given that we are unable to secure parts for your repair…” that could be considered controversial. Admittedly, quantities of these items can run out and eventually particular watch models may become unserviceable. Such parts could include movements, hands, dials, bracelets, and items that would have been produced many years ago for that watch. It continues to say that “…or that we no longer have parts in stock to repair.” This clause might imply that the watch is broken and might require special parts specific to that model to make it work again. This statement is true because the Hunter Mach 3 watches were made in the early 2000s. ![]() We’ll start on the first paragraph, which states “Regrettably, this is a vintage model that is either discontinued…”. 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![]() The voice cast includes Yuri Lowenthal (He-Man/Adam/Tuvar), David Kaye (Cringer/Battle Cat), Grey Griffin (Evelyn/Evil-Lyn), Antony Del Rio (Duncan/Man-at-Arms), Kimberly Brooks (Teela/Eldress/Sorceress), Trevor Devall (R’Qazz/Beast Man), Judy Alice Lee (Krass/Ram Ma’am), Roger Craig Smith (Kronis/Trap-Jaw/General Dolos), Fred Tatasciore (King Randor/Baddrah), Ben Diskin (Skeletor/Prince Keldor), Tom Kenny (Ork-0/RK Units), Max Mitchell (Kitty), and Max Stubington (Young Adam). Probably following more of the style from Revelations where it’s marketed to older fans but created for some audience that doesn’t exist. Telltale Games and Deck Nine shared a new gameplay trailer during Gamescom. 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